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Administration
May be taken with or without food.
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Contraindications
Hypersensitivity; active liver disease or unexplained persistent elevated liver function tests. Pregnancy and lactation.
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Special Precautions
Hepatic impairment; patients consuming substantial quantities of alcohol with a history of liver disease. Not recommended for use in children <10 yr.
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Adverse Reactions
Headache, flatulence, dyspepsia, myalgia, rash, pruritus, allergy and infection. Abdominal discomfort, asthenia, constipation, diarrhoea, back pain, arthralgia, resp infection and fatigue.
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Drug Interactions
Atorvastatin: Increases digoxin levels; increases anticoagulant effect of warfarin. Avoid the combination of HMG-CoA reductase inhibitors and fibrates. Ezetimibe: Cholestyramine decreases AUC of ezetimibe by approx 55%; ciclosporin may increase ezetimibe levels.
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CIMS Class
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ATC Classification
C10AX09 - ezetimibe ; Belongs to the class of other lipid modifying agents.
C10AA05 - atorvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia. |
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